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KMID : 1134820000290010153
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 1 p.153 ~ p.160
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Cytotoxicity of Daucus carota L. on Various Cancer Cells
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Han Eun-Joo
Rho Sung-Bae
Bae Song-Ja
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Abstract
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We investigated the cytotoxic effects of roots and seeds Daucus carota L. on HepG2, HeLa, MCF7, SW626, C6 and NB41A3 cell lines by the MTT assay. Among extracts, the ethylacetate partition layer (DCMEA) of root of Daucus carota L. showed the strongest cytotoxic effects on HepG2, HeLa, C6 and NB41A3 cell lines. On the other hand, methanol(DCM), n-ethylacetate(DCMEA) and n-butanol(DCMB) extract of the seeds of Daucus carota L. also showed significant cytotoxic activities for all six cell lines. β-carotene, a well-known main component of Daucus carota L. was also tested for its cytotoxic effect. However, in all six cell lines, β-carotene falied to show significant cytotoxicity. Therefore, the anticancer effect of DCMEA of root of Daucus carota L. and DCM, DCMH, DCMEA and DCMB extracts of seeds may be caused by components other than β-carotene. Futher studies are under way to isolate the com- pounds responsible for the significant cytotoxic activity.
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KEYWORD
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cytotoxicity, Daucus carota L., cancer cells
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